The goals are to improve care and understanding
… but papers are the currency of research
Chen G, Deutsch G, Schulert GS, Zheng H, Jang S, Trapnell B, Lee P, Macaubas C, Ho K, Schneider C, Saper VE, de Jesus AA, Krasnow M, Grom AA, Goldbach-Mansky R, Khatri P#, Mellins ED#, Canna SW#. Serum proteome analysis of Systemic JIA and related lung disease identifies distinct inflammatory programs and biomarkers. Arthritis & Rheumatology 2022. Epub 2/21/22. PMID: 35189047 link
#equal contribution
Van Der Kraak LA, Schneider C, Dang V, Burr AHP, Weiss ES, Hand TW, Canna SW. Genetic and commensal induction of IL-18 drive intestinal epithelial MHCII via IFNg. Mucosal Immunology 2021. Epub Jun 8. PMID: 34103660 link
Tsoukas P, Rapp E, Van Der Kraak L, Weiss E, Dang V, Schneider C, Klein E, Picarsic J, Salcedo R, Stewart CA, Canna SW: Interleukin-18 and cytotoxic impairment are independent and synergistic causes of murine virus-induced hyperinflammation. Blood. Online ahead of print (eds.). 136(19): 2162-2174, Nov 2020 link
Featured in: Behrens EM. The Perfect Storm. Blood. link
Weiss, E. S., Girard-Guyonvarc'h, C., Holzinger, D., de Jesus, A. A., Tariq, Z., Picarsic, J., Schiffrin, E. J., Foell, D., Grom, A. A., Ammann, S., Ehl, S., Hoshino, T., Goldbach-Mansky, R., Gabay, C., & Canna, S. W. (2018). Interleukin-18 diagnostically distinguishes and pathogenically promotes human and murine macrophage activation syndrome. Blood, 131(13), 1442–1455. link
Featured in: McClain KL & Allen CE. Fire behind the fury: IL-18 and MAS. Blood 2020 link
Canna, S. W., Girard, C., Malle, L., de Jesus, A., Romberg, N., Kelsen, J., Surrey, L. F., Russo, P., Sleight, A., Schiffrin, E., Gabay, C., Goldbach-Mansky, R., & Behrens, E. M. (2017). Life-threatening NLRC4-associated hyperinflammation successfully treated with IL-18 inhibition. The Journal of allergy and clinical immunology, 139(5), 1698–1701. link
Canna SW, de Jesus AA, Gouni S, Brooks SR, Marrero B, Liu Y, DiMattia MA, Zaal KJ, Sanchez GA, Kim H, Chapelle D, Plass N, Huang Y, Villarino AV, Biancotto A, Fleisher TA, Duncan JA, O'Shea JJ, Benseler S, Grom A, Deng Z, Laxer RM, Goldbach-Mansky R. An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome. Nat Genet. 2014 Oct;46(10):1140-6. link
Featured in: Khameneh & Mortellaro A. NLRC4 gets out of control. Nat Genet 2014. link
& Bernard NJ. NLRC4 mutation causes rare autoinflammatory disease. Nat Rev Rheum. 2020 link
Goldbach-Mansky R, Dailey NJ, Canna SW, Gelabert A, Jones J, Rubin BI, Kim HJ, Brewer C, Zalewski C, Wiggs E, Hill S, Turner ML, Karp BI, Aksentijevich I, Pucino F, Penzak SR, Haverkamp MH, Stein L, Adams BS, Moore TL, Fuhlbrigge RC, Shaham B, Jarvis JN, O'Neil K, Vehe RK, Beitz LO, Gardner G, Hannan WP, Warren RW, Horn W, Cole JL, Paul SM, Hawkins PN, Pham TH, Snyder C, Wesley RA, Hoffmann SC, Holland SM, Butman JA, Kastner DL. Neonatal-onset multisystem inflammatory disease responsive to interleukin-1beta inhibition. N Engl J Med. 2006 Aug 10;355(6):581-92.
RECENT REVIEWS
Henderson LA*, Canna SW*, Schulert GS, Volpi S, Lee PY, Kernan KF, et al., On the Alert for Cytokine Storm: Immunopathology in COVID-19. Arth Rheum 2020 Jul:72(7):1059-1063. *Equal contribution
Canna SW, Cron RQ: Highways to hell: mechanism based management of Cytokine Storm Syndromes J Allergy Clin Immunol 146(5): 949-959, November 2020.
Canna S, Marsh R: Pediatric Hemophagocytic Lymphohistiocytosis (HLH). Blood 135(16): 1332-11343, April 2020.
de Jesus AA, Canna SW, Liu Y, Goldbach-Mansky R. Molecular mechanisms in genetically defined autoinflammatory diseases: disorders of amplified danger signaling. Annu Rev Immunol. 2015;33:823-74.
Full list of publications:
https://www.ncbi.nlm.nih.gov/myncbi/1fiotpzqdxXk2/bibliography/public/